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Home Science & Tech

ZyCoV-D vaccine

August 24, 2021
in Science & Tech
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ZyCoV-D vaccine
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In news- Ahmedabad-based Zydus Cadila on Friday received emergency use authorization from the drug controller for its three-dose, intradermal, ZyCoV-D Covid-19 vaccine.

About ZyCoV-D vaccine-

  • It is the world’s first plasmid DNA-based shot and India’s indigenously developed DNA-based vaccine.
  • It uses a section of genetic material from the virus that gives instructions as either DNA or RNA to make the specific protein that the immune system recognises and responds to.
  • It is India’s sixth approved Covid shot after Covishield, Covaxin, Sputnik V, Moderna and Johnson and Johnson.
  • It has been developed in partnership with the Department of Biotechnology and is the second home-grown shot to get emergency authorisation in India after Bharat Biotech’s Covaxin.
  • It has a needle-free application system manufactured by Pharma Jet in place to administer the shots.
  • It will be using a specific model called the ‘Tropis’, which received regulatory approval in Europe in 2017.
  • On July 1, Zydus Cadila had applied for approval for emergency use and conducted the largest clinical trial for its vaccine, including on population in the age group of 12-18. 
  • This was also the first time that any Covid-19 vaccine was tested in the adolescent population.
  • Primary efficacy of 66.6 percent has been attained for symptomatic RT-PCR positive cases in the interim analysis.
  • Both the Phase I/II and Phase III clinical trials have been monitored by an independent Data Safety Monitoring Board (DSMB).

What is the Tropis needle-free system?

  • Tropis delivers vaccines intradermally, technology that propels liquid at high pressure to deliver vaccines through the skin without utilising needles. 
  • There are three components: the injector, the needle-free syringe, and a filling adapter.
  • The vaccine is administered using a simple four-step process: prepare the injector; fill the syringe; load the injector, and give the injection at the Deltoid region.
  • A needle-free injector is said to be more accurate and requires little training. 
  • It reduces the infection-associated anxiety for the beneficiary and the vaccinator. 
  • It also does not give rise to any needlestick injuries to the health care workers. 

Each needle-free syringe is sterile, auto disabling, and cannot be reused.

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Source: The Hindu
Tags: News PaperPrelims

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