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Home Science & Tech

Repurposed Drugs

October 19, 2020
in Science & Tech
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Repurposed Drugs
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Recently, WHO states that repurposed drugs did not cut down mortality due to COVID-19

What is it?

  • Drug repurposing(profiling) is is a strategy for identifying new uses for approved or investigational drugs that are outside the scope of the original medical indication
  • This strategy offers various advantages over developing an entirely new drug for a given indication
  • Drug repositioning is a “universal strategy” for neglected diseases due to 
    • Reduced number of required clinical trial steps could reduce the time and costs for the medicine to reach the market
    • Existing pharmaceutical supply chains could facilitate “formulation and distribution” of the drug
    • Known possibility of combining with other drugs could allow more effective treatment, 
    • The repositioning could facilitate the discovery of “new mechanisms of action for old drugs and new classes of medicines”
    • The removal of “activation barriers” of early research stages can enable the project to advance rapidly into disease-oriented research.

Some of the examples of repurposed drugs are:

  • A number of successes have been achieved, the foremost including sildenafil (Viagra) for erectile dysfunction and pulmonary hypertension and thalidomide for leprosy and multiple myeloma
  • Others are Remdesivir, Hydroxychloroquine, Lopinavir/Ritonavir(not successful)
Source: The Hindu
Tags: Prelims

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