• 9964432222
  • Mail Us
  • Appointment
  • Locate Us
  • Chat Now
  • Courses
  • Login
  • Register
Manifest IAS
JournalsOfIndia
Advertisement
  • Home
  • SNIPPETSfor Prelims
  • ARTICLESfor Mains
  • BROWSEBY SOURCE
  • DOWNLOADS
No Result
View All Result
  • Home
  • SNIPPETSfor Prelims
  • ARTICLESfor Mains
  • BROWSEBY SOURCE
  • DOWNLOADS
No Result
View All Result
JournalsOfIndia
No Result
View All Result
Home Science & Tech

Factor D Protein: Covid-19

January 25, 2021
in Science & Tech
Reading Time: 2min read
0
Factor D Protein: Covid-19
158
VIEWS
Share on WhatsAppShare on TelegramShare on Facebook

In News

  • A new study by Johns Hopkins Medicine researchers suggests that blocking a human protein factor D may reduce the deadly inflammatory reactions that many patients have due to COVID-19.

Key Points

  • Method: The new study used normal human blood serum and three subunits of the SARS-CoV-2 spike protein to discover exactly how the virus hijacks the immune system and endangers normal cells.
  • Focus: Team focused on two proteins, factor H and factor D, which are known as “complement” proteins, because they help the immune system clear pathogens from the body.
  • Findings: The researchers discovered that Covid-19’s spike protein causes factor D to overstimulate the immune response, which in turn prevents factor H from mediating that response.
  • Spike proteins on the surface of SARS-CoV-2 are the means by which it attaches to cells targeted for infection.
  • The spikes first grab hold of a molecule called heparan sulfate.
  • Facilitated by its initial binding with heparan sulfate, SARS-CoV-2 then uses another cell-surface component, the protein known as angiotensin-converting enzyme 2 (ACE2), as its doorway into the attacked cell.
  • When SARS-CoV-2 attacks the ACE2 receptors to proliferate and infect more cells in the human body, it also prevents Factor H from using the sugar molecule to bind with cells.
  • The team found that by blocking factor D, they were able to stop the destructive chain of events triggered by SARS-CoV-2.

Important Terms

Heparan sulfate is a large, complex sugar molecule found on the surface of cells in the lungs, blood vessels and smooth muscle making up most organs.

ACE2

  • ACE2 is a protein on the surface of many cell types.
  • It is an enzyme that generates small proteins – by cutting up the larger protein angiotensinogen – that then go on to regulate functions in the cell.

Factor H’s main function is to regulate the chemical signals that trigger inflammation and keep the immune system from harming healthy cells.

 

Source: Indian Express
Tags: News PaperPrelims

Related Posts

Gliese 486b

Gliese 486b

March 6, 2021
Indian Pathogen Priority List

Indian Pathogen Priority List

March 5, 2021
Aries-Devasthal Faint Object Spectrograph & Camera (ADFOSC)

Aries-Devasthal Faint Object Spectrograph & Camera (ADFOSC)

March 5, 2021
Nanophotonics or Nano Optics

Nanophotonics or Nano Optics

March 3, 2021
Johnson and Johnson COVID vaccine

Johnson and Johnson COVID vaccine

March 2, 2021
Pixel India’s Anand satellite

Pixel India’s Anand satellite

March 2, 2021
National Council for Science Technology Communication (NCSTC)

National Council for Science Technology Communication (NCSTC)

March 1, 2021
PSLV-C51/Amazonia-1 Mission

PSLV-C51/Amazonia-1 Mission

March 1, 2021
Vaccine phase 2

Vaccine phase 2

February 26, 2021
National Tuberculosis Elimination Programme (NTEP)

National Tuberculosis Elimination Programme (NTEP)

February 25, 2021
Please login to join discussion
March 2021
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
293031 
« Feb    

Browse by Category

  • Agriculture
  • Disaster Management
  • Economy
  • Environment
  • Ethics
  • Foreign Affairs
  • Geography
  • Governance
  • History
  • Law & Policy
  • Opinion
  • People in News
  • Places in News
  • Science & Tech
  • Security
  • Society

Browse by Tags

AIR Down to Earth GS-1 GS-2 GS-3 GS-4 Kurukshetra Mains News Paper PIB Prelims PRS India RSTV Science Reporter Survey Yojana
JournalsOfIndia

Our vision is to orient the readers to grasp the facts objectively and analyse critically. In the rush of reaching first to the readers, the websites miss the balanced opinion, which is the need of the hour. We aim to reach the readers with more crispness, preciseness and relevance. We bring the articles in UPSC way for the civil services aspirants and the Wisest Way for general readers.

Categories

  • Agriculture
  • Disaster Management
  • Economy
  • Environment
  • Ethics
  • Foreign Affairs
  • Geography
  • Governance
  • History
  • Law & Policy
  • Opinion
  • People in News
  • Places in News
  • Science & Tech
  • Security
  • Society

Browse by Tag

AIR Down to Earth GS-1 GS-2 GS-3 GS-4 Kurukshetra Mains News Paper PIB Prelims PRS India RSTV Science Reporter Survey Yojana

Newsletter

The most important UPSC news and events of the day.

Get Journals daily newsletter on your inbox.

© 2020 JournalsOfIndia - A free initiative by Manifest Team.

  • Login
  • Sign Up
  • Home
  • SNIPPETS
  • ARTICLES
  • BROWSE
  • DOWNLOADS
No Result
View All Result

© 2020 JournalsOfIndia - A free initiative by Manifest Team.

Welcome Back!

Login to your account below

Forgotten Password? Sign Up

Create New Account!

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In